Disease-focused Programs

Crohn's Disease

HITI’s third Request for Applications of pilot awards were awarded in May 2014. The RFA focused on providing seed funding for collaborative pilot grants utilizing either the collaborative research project approach or the program project approach. The following researchers were funded:

Bruce Horwitz, Brigham and Women's Hospital
A Pipeline for Therapeutic Manipulation of Regulatory Pathways in IBD

Efi Kokkotou, Beth Israel Deaconess Medical Center
Development and Validation of a Precision Medicine Tool in Crohn's Therapeutics

Steven Shoelson, Joslin Diabetes Center
Modulating Gut Inflammation via Fast-Induced Suppression of Commensal Pathobionts

Timothy A. Springer, Boston Children's Hospital
α4β7 Integrin Closing Inhibitors as Novel Small Molecule Crohn's Disease Therapeutics

Hanno Steen, Boston Children's Hospital
Identifying Urinary Biomarkers for Crohn's Disease

Junying Yuan, Harvard Medical School
Targeting RIP1 Kinase for the Treatment of Crohn’s Disease 

HITI’s second Request for Applications of pilot awards were awarded in December 2012. The RFA focused on providing seed funding for new research program project grants to support integrated, multi-project research teams involving a number of independent investigators who will share knowledge and resources generated through their work together. The selected program project grants and their program directors are as follows:

Vijay Kuchroo, Brigham and Women’s Hospital
Role of High Salt Diet and Other Dietary Risk Factors in the Development of Crohn's Disease

Simon Robson, Beth Israel Deaconess Medical Center
The Host Response to Fecal Biotherapy in Patients with Crohn’s Disease

Scott Snapper, Boston Children’s Hospital
The Very Early Onset Inflammatory Bowel Disease Project

Harland Winter, Massachusetts General Hospital
Applying Systems Biology to Discover Causal Pathophysiological Pathways, Novel Biomarkers, Genes, and Therapeutic Targets in Newly-diagnosed, Treatment-naïve, Pediatric Crohn’s Disease

HITI’s first round of pilot awards for research on Crohn’s disease were announced on May 20, 2011. The following researchers were funded:

"This was an opportunity for me
to begin work in a new area -
with new collaborators -
an exciting opportunity."

Jeff Karp

"For traditional (NIH) funding
mechanisms funding is offered
after the tools are in place.
HITI provided the funds needed
to develop the tools."

Jon Kagan

David Breault, Children’s Hospital Boston, and Jeffrey Karp, Brigham and Women’s Hospital
Towards Regenerative Therapeutics for Inflammatory Bowel Disease: The Role of Stem Cells in vivo and in Bio-engineered Intestinal Epithelium

Laurie Glimcher, Harvard School of Public Health
A Translational Approach for the Identification of Novel Genes and Rare Variants of these Genes Associated with Crohn's Disease

Dimitrios Iliopoulos, Dana-Farber Cancer Institute
Identification of Novel Molecular Circuits that Link Inflammation to Colon Cancer

Jonathan Kagan, Boston Children’s Hospital
Zinc Finger Nucleases as Tools to Uncover the Functions of Crohn’s Susceptibility Genes

Bruce Paster, Forsyth Institute
Oral Microbial Biomarkers for Crohn’s Disease in Children

Shiv Pillai, Massachusetts General Hospital
The SIAE Pathway and Beyond: Rare Genetic Variants and the Potential for New Therapies in Crohn's Disease

Vijay Yajnik, Massachusetts General Hospital, and Matthew Meyerson, Dana-Farber Cancer Institute
Pathogen Discovery in Crohn's Disease by Next-Generation Sequencing