2024 |
| In Vivo CRISPR Screening Reveals CHD7 as a Positive Regulator of Short-lived Effector Cells: J Immunology |
| Decline of Mpox Antibody Responses After Modified Vaccinia Ankara-Bavarian Nordic Vaccination: JAMA |
| Safety and antiviral effect of a triple combination of HIV-1 broadly neutralizing antibodies: a phase 1/2a trial: Nature Medicine |
| Insights from an observational translational research program during the COVID-19 pandemic: Four years of experience: Vaccine |
| A chemogenetic screen reveals that Trpv1-expressing neurons control regulatory T cells in the gut: Science |
| Charting the cellular biogeography in colitis reveals fibroblast trajectories and coordinated spatial remodeling: Cell |
| Comparison of the immunogenicity and protective efficacy of ACAM2000, MVA, and vectored subunit vaccines for Mpox in rhesus macaques: Science Translational Medicine |
| AIRE relies on Z-DNA to flag gene targets for thymic T cell tolerization: Nature |
| Joint analysis of mutational and transcriptional landscapes in human cancer reveals key perturbations during cancer evolution: Genome Biol |
| International Harrington Prize Awarded to Dr. Arlene Sharpe: Harrington Discovery Institute |
| Framework for in vivo T cell screens: JEM |
| Waning immunity and IgG4 responses following bivalent mRNA boosting: Science Advances |
| Gut complement induced by the microbiota combats pathogens and spares commensals: Cell |
| Adipose-tissue regulatory T cells are a consortium of subtypes that evolves with age and diet: PNAS |
| Antibody production relies on the tRNA inosine wobble modification to meet biased codon demand: Science |
| A dynamic atlas of immunocyte migration from the gut: Science Immunology |
2023 |
| Targeting of the CD161 Inhibitory Receptor Enhances T cell-mediated Immunity Against Hematological Malignancies: Blood |
| Mucosal boosting enhances vaccine protection against SARS-CoV-2 in macaques: Nature |
| Lymph node stromal cell responses to perinatal T cell waves, a temporal atlas: PNAS |
| Homeostatic, repertoire and transcriptional relationships between colon T regulatory cell subsets: PNAS |
| X-CHIME enables combinatorial, inducible, lineage-specific and sequential knockout of genes in the immune system: Nature Immunology |
S. aureus drives itch and scratch-induced skin damage through a V8 protease-PAR1 axis: Cell Further coverage: HMS News & Research |
| Dennis Kasper wins Albany Prize for microbiome research: HMS News & Research |
| A discrete ‘early-responder’ stromal-cell subtype orchestrates immunocyte recruitment to injured tissue: Nature Immunology |
Regulatory T cells shield muscle mitochondria from interferon-γ–mediated damage to promote the beneficial effects of exercise: Science Immunology Further coverage: HMS news |
| Dennis Kasper named recipient of the 2024 Paul Ehrlich and Ludwig Darmstaedter Prize: HMS News & Research |
| Mpox infection protects against re-challenge in rhesus macaques: Cell |
| Formate supplementation enhances anti-tumor CD8+ T cell fitness and efficacy of PD-1 blockade: Cancer Discovery |
The International Union of Immunological Societies and its Gender Equality Committee have announced Diane Mathis as the inaugural winner of the Menarini Prize for Outstanding Woman Immunologist Further coverage: IUIS.org |
Gut microbial fatty acid isomerization modulates intraepithelial T cells: Nature Further coverage: When It Comes to Immunity, You Are What You Eat |
| The interweaved signatures of common-gamma-chain cytokines across immunologic lineages: JEM |
Targeting PD-L2-RGMb overcomes microbiome-related immunotherapy resistance: Nature Further coverage: To Boost Cancer Immunotherapy’s Fighting Power, Look to the Gut |
| Addressing Tumor Heterogeneity by Sensitizing Resistant Cancer Cells to T cell-Secreted Cytokines: Cancer Discovery |
Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration: Neuron Further coverage: Innate Immune Molecule Implicated in ALS Neurodegeneration |
| The gut microbiota promotes distal tissue regeneration via RORγ+ regulatory T cell emissaries: Immunity |
| Treg cells require Izumo1R to regulate γδT cell-driven inflammation in the skin: PNAS |
| cIAP1/2 Antagonism Induces Antigen-Specific T Cell-Dependent Immunity: J. Immunology |
| Multimodal control of dendritic cell functions by nociceptors: Science |
| IFNγ is a central node of cancer immune equilibrium: Cell Rep |
Bacteria hijack a meningeal neuroimmune axis to facilitate brain invasion: Nature Further coverage: Meningitis Bacteria Trigger Headaches, Then Sneak Into the Brain |
| PD-1 blockade and CDK4/6 inhibition augment nonoverlapping features of T cell activation in cancer: JEM |
| Substantial Neutralization Escape by SARS-CoV-2 Omicron Variants BQ.1.1 and XBB.1: NEJM |
| Immunogenicity of BA.5 Bivalent mRNA Vaccine Boosters: NEJM |
| Definition of the contribution of an Osteopontin-producing CD11c+ microglial subset to Alzheimer's disease: PNAS |
| Altered Cytokine Production in Human Intervillous Blood T Cells in Preeclampsia: Reproductive Science |
2022 |
| Of the top 100 women scientists in the world, three of them are in the HMS Department of Immunology. Congratulations to Drs. Laurie Glimcher, Diane Mathis, and Arlene Sharpe: Research |
| Ruaidhri Jackson received a Harvard Medical School 2022 Excellence in Mentoring Young Mentor Award: DICP |
| Impact of the Host Microbiome on Vaccine Responsiveness: Lessons Learned and Future Perspective: Biochemistry |
| Thymic epithelial cells co-opt lineage-defining transcription factors to eliminate autoreactive T cells: Cell |
| Quiescent cancer cells resist T cell attack by forming an immunosuppressive niche: Cell |
| Human gut bacteria produce ΤΗ17-modulating bile acid metabolites: Nature |
| Identification of MicroRNAs That Stabilize p53 in Human Papillomavirus-Positive Cancer Cells: Journal of Virology |
| Research suggests role for anthrax in fighting pain: The Harvard Gazette |
| FoxP3 associates with enhancer-promoter loops to regulate Treg-specific gene expression: Science Immunology |
2021 |
| Tissue eosinophils express the IL-33 receptor ST2 and type 2 cytokines in patients with eosinophilic esophagitis : Allergy |
| Maternal gut bacteria drive intestinal inflammation in offspring with neurodevelopmental disorders by altering the chromatin landscape of CD4+ T cells: Immunity |
| Vaccination in a humanized mouse model elicits highly protective PfCSP-targeting anti-malarial antibodies: Immunity |
| Host immunomodulatory lipids created by symbionts from dietary amino acids: Nature |
| Specialized transendothelial dendritic cells mediate thymic T-cell selection against blood-borne macromolecules: Nature Communications |
| A bacterial bile acid metabolite modulates Treg activity through the nuclear hormone receptor NR4A1: Cell Host & Microbe |
| Interferon-α-producing plasmacytoid dendritic cells drive the loss of adipose tissue regulatory T cells during obesity: Cell Metabolism |
| Not-so-opposite ends of the spectrum: CD8+ T cell dysfunction across chronic infection, cancer and autoimmunity: Nature Immunology |
| cIAP1/2 antagonism eliminates MHC class I-negative tumors through T cell-dependent reprogramming of mononuclear phagocytes: Sci Transl Med |
| Microbes in your gut may be new recruits in the fight against viruses: National Geographic |
| Single-cell analysis of FOXP3 deficiencies in humans and mice unmasks intrinsic and extrinsic CD4 + T cell perturbations: Nature Immunology |
| PPARγ marks splenic precursors of multiple nonlymphoid-tissue Treg compartments: PNAS |
| The CysLT2R receptor mediates leukotriene C4-driven acute and chronic itch: PNAS |
| Maternal immune activation in mice disrupts proteostasis in the fetal brain: Nature Neuroscience |
| The intestinal neuro-immune axis: Crosstalk between neurons, immune cells, and microbes: Mucosal Immunology |
| Facundo Batista appointed Chief Editor of The EMBO Journal: EMBO Journal |
| Gut CD4+ T cell phenotypes are a continuum molded by microbes, not by TH archetypes: Nature Immunology |
2020 |
| Lymph nodes are innervated by a unique population of sensory neurons with immunomodulatory potential: Cell |
| Fiber Sets up the Battleground for Intestinal Prevotella: Cell Host & Microbe |
| Commensal Microbiota Modulation of Natural Resistance to Virus Infection: Cell |
| Transcriptional and proteomic insights into the host response in fatal COVID-19 cases: PNAS |
| Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamsters: Nature Medicine |
| A bilateral tumor model identifies transcriptional programs associated with patient response to immune checkpoint blockade: PNAS |
| XBP-1 and the unfolded protein response (UPR): Nature Immunology |
| The PD-1 Pathway Regulates Development and Function of Memory CD8+T Cells following Respiratory Viral Infection: Cell Reports |
| Molecular Pathways of Colon Inflammation Induced by Cancer Immunotherapy: Cell |
| Vaccines can protect against COVID-19 in nonhuman primates, study says: Harvard Gazette |
| When Lab Mice Go Wild, Fungi Are in Play: Cell Host & Microbe |
| An immunologic mode of multigenerational transmission governs a gut Treg setpoint: Cell |
| The Society for Immunotherapy of Cancer Announces Three Recipients of the 2020 Richard V. Smalley, MD, Memorial Award and Lectureship: SITC |
| Neuro-immune Interactions in the Tissues: Immunity |
| Neuronal, stromal, and T-regulatory cell crosstalk in murine skeletal muscle: PNAS |
| Sex-specific adipose tissue imprinting of regulatory T cells: Nature |
| Potent Zika and dengue cross-neutralizing antibodies induced by Zika vaccination in a dengue-experienced donor: Nature Medicine |
| Flesh-eating bacteria is real and this is how it works: Seeker |
| Profile of Dennis L. Kasper: PNAS |
| Maternal microbiome protects newborns from deadly diarrheal infections: Genetic Engineering & Biotechnology News |
| Microbiota-targeted maternal antibodies protect neonates from enteric infection: Nature |
2019 |
| Bile Acid Metabolites Keep the Gut’s T Cells in Good Humor: Genetic Engineering & Biotechnology News |
| Microbial bile acid metabolites modulate gut RORγ+ regulatory T cell homeostasis: Nature |
| Evaluation of a mosaic HIV-1 vaccine in a multicentre, randomised, double-blind, placebo-controlled, phase 1/2a clinical trial (APPROACH) and in rhesus monkeys (NHP 13-19): Lancet |
| T cell receptor specificity drives accumulation of a reparative population of regulatory T cells within acutely injured skeletal muscle: PNAS |
| Symbionts exploit complex signaling to educate the immune system: PNAS |
| Gut-Innervating Nociceptor Neurons Regulate Peyer’s Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense: Cell |
| Bile acid metabolites control TH17 and Treg cell differentiation: Nature |
| NMD Takes the Immune Road to NDD: Neuron |
| Control of Germinal Center Localization and Lineage Stability of Follicular Regulatory T Cells by the Blimp1 Transcription Factor: Cell Reports |
| The Immune-Mind Connection: Cell |
| A New Actor in Cancer Immunity: HMS News |
| T cell activation depends on extracellular alanine: Cell Reports |
| PTPN2 regulates the generation of exhausted CD8+ T cell subpopulations and restrains tumor immunity: Nature |
| Lack of therapeutic efficacy of an antibody to α4β7 in SIVmac251-infected rhesus macaques: Science |
| Programmable bacteria as cancer therapy: Nature |
| Transnuclear mice reveal Peyer's patch iNKT cells that regulate B-cell class switching to IgG1: EMBO Journal |
| Mast Cells Get on Your Nerves in Itch: Immunity |
| Microbiome-on-a-Chip Paves Way for Personalized Medicine: Technology Networks |
| The IRE1 endoplasmic reticulum stress sensor activates natural killer cell immunity in part by regulating c-Myc: Nature Immunology |
| Structural topology defines protective CD8+ T cell epitopes in the HIV proteome : Science |
| Could inflammation be the cause of myriad chronic conditions?: Harvard Magazine |
| Arlene Sharpe's Science Helps Cancer Patients, And 'It Doesn't Get Better Than That': WBUR |
| GM-CSF, IL-3, and IL-5 Family of Cytokines: Regulators of Inflammation: Immunity |
| Dougan Discusses Augmenting T-Cell Activity in Pancreatic Cancer: OneLive |
| Cracking Tumor Defiance: Harvard News & Research |
2018 |
| Advancing Research in Neurodegenerative Diseases: Harvard News & Research |
| Out of One, Two. New preclinical departments emerge from MBIB: Harvard News & Research |
| Spurring Innovation. $14M in dean’s grants awarded to boost scientific collaborations: Harvard News & Research |
| Combination therapy targets latent reservoir of HIV: BIDMC News |
| Molecular diversification of regulatory T cells in nonlymphoid tissues: Science Immunology |
| Subversive Maneuvers. Study reveals how the germ behind flesh-eating disease hijacks neurons to avoid immune destruction and ensure its own survival: Harvard News & Research |
| Personal cancer vaccines show promise: The Harvard Gazette |
| 4 HMS Faculty Elected to NAS: Harvard News & Research |
| More Options For Cancer Immunotherapy: Science Friday |
| Deadly Crosstalk. Nerve cells found to suppress immune response during lethal lung infections: Harvard News & Research |
| The SMC5/6 Complex Interacts with the Papillomavirus E2 Protein and Influences Maintenance of Viral Episomal DNA: Journal of Virology |
2017 |
| Needle in a Haystack. Research paves way to understanding of cause and effect between gut microbes and disease: Harvard News & Research |
| Studies help explain link between autism, severe infection during pregnancy: MIT News |
| Protecting the Guardians. Gut bacteria can alter the protective effects of a gene that wards off type 1 diabetes: Harvard News & Research |
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