International Harrington Prize Awarded to Dr. Arlene Sharpe: Harrington Discovery Institute

Framework for in vivo T cell screens: JEM

Waning immunity and IgG4 responses following bivalent mRNA boosting: Science Advances

Gut complement induced by the microbiota combats pathogens and spares commensals: Cell

Adipose-tissue regulatory T cells are a consortium of subtypes that evolves with age and diet: PNAS

Antibody production relies on the tRNA inosine wobble modification to meet biased codon demand: Science

A dynamic atlas of immunocyte migration from the gut: Science Immunology


Targeting of the CD161 Inhibitory Receptor Enhances T cell-mediated Immunity Against Hematological Malignancies: Blood

Mucosal boosting enhances vaccine protection against SARS-CoV-2 in macaques: Nature

Lymph node stromal cell responses to perinatal T cell waves, a temporal atlas: PNAS

Homeostatic, repertoire and transcriptional relationships between colon T regulatory cell subsets: PNAS

X-CHIME enables combinatorial, inducible, lineage-specific and sequential knockout of genes in the immune system: Nature Immunology

S. aureus drives itch and scratch-induced skin damage through a V8 protease-PAR1 axis: Cell

Further coverage: HMS News & Research

Dennis Kasper wins Albany Prize for microbiome research: HMS News & Research

A discrete ‘early-responder’ stromal-cell subtype orchestrates immunocyte recruitment to injured tissue: Nature Immunology

Regulatory T cells shield muscle mitochondria from interferon-γ–mediated damage to promote the beneficial effects of exercise: Science Immunology

Further coverage: HMS news

Dennis Kasper named recipient of the 2024 Paul Ehrlich and Ludwig Darmstaedter Prize:  HMS News & Research

Mpox infection protects against re-challenge in rhesus macaques: Cell

Formate supplementation enhances anti-tumor CD8+ T cell fitness and efficacy of PD-1 blockade: Cancer Discovery

The International Union of Immunological Societies and its Gender Equality Committee have announced Diane Mathis as the inaugural winner of the Menarini Prize for Outstanding Woman Immunologist

Further coverage: IUIS.org

Gut microbial fatty acid isomerization modulates intraepithelial T cells: Nature

Further coverage: When It Comes to Immunity, You Are What You Eat

The interweaved signatures of common-gamma-chain cytokines across immunologic lineages: JEM

Targeting PD-L2-RGMb overcomes microbiome-related immunotherapy resistance: Nature

Further coverage: To Boost Cancer Immunotherapy’s Fighting Power, Look to the Gut

Addressing Tumor Heterogeneity by Sensitizing Resistant Cancer Cells to T cell-Secreted Cytokines: Cancer Discovery

Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration: Neuron

Further coverage: Innate Immune Molecule Implicated in ALS Neurodegeneration

The gut microbiota promotes distal tissue regeneration via RORγ+ regulatory T cell emissaries: Immunity

Treg cells require Izumo1R to regulate γδT cell-driven inflammation in the skin: PNAS

cIAP1/2 Antagonism Induces Antigen-Specific T Cell-Dependent Immunity: J. Immunology

Multimodal control of dendritic cell functions by nociceptors: Science

IFNγ is a central node of cancer immune equilibrium: Cell Rep

Bacteria hijack a meningeal neuroimmune axis to facilitate brain invasion: Nature

Further coverage: Meningitis Bacteria Trigger Headaches, Then Sneak Into the Brain

PD-1 blockade and CDK4/6 inhibition augment nonoverlapping features of T cell activation in cancer: JEM

Substantial Neutralization Escape by SARS-CoV-2 Omicron Variants BQ.1.1 and XBB.1: NEJM

Immunogenicity of BA.5 Bivalent mRNA Vaccine Boosters: NEJM

Definition of the contribution of an Osteopontin-producing CD11c+ microglial subset to Alzheimer's disease: PNAS

Altered Cytokine Production in Human Intervillous Blood T Cells in Preeclampsia: Reproductive Science

Of the top 100 women scientists in the world, three of them are in the HMS Department of Immunology. Congratulations to Drs. Laurie Glimcher, Diane Mathis, and Arlene Sharpe: Research
Ruaidhri Jackson received a Harvard Medical School 2022 Excellence in Mentoring Young Mentor Award: DICP
Impact of the Host Microbiome on Vaccine Responsiveness: Lessons Learned and Future Perspective: Biochemistry
Thymic epithelial cells co-opt lineage-defining transcription factors to eliminate autoreactive T cells: Cell
Quiescent cancer cells resist T cell attack by forming an immunosuppressive niche: Cell
Human gut bacteria produce ΤΗ17-modulating bile acid metabolites: Nature
Identification of MicroRNAs That Stabilize p53 in Human Papillomavirus-Positive Cancer Cells: Journal of Virology
Research suggests role for anthrax in fighting pain: The Harvard Gazette
FoxP3 associates with enhancer-promoter loops to regulate Treg-specific gene expression: Science Immunology
Tissue eosinophils express the IL-33 receptor ST2 and type 2 cytokines in patients with eosinophilic esophagitis : Allergy
Maternal gut bacteria drive intestinal inflammation in offspring with neurodevelopmental disorders by altering the chromatin landscape of CD4+ T cells: Immunity
Vaccination in a humanized mouse model elicits highly protective PfCSP-targeting anti-malarial antibodies: Immunity
Host immunomodulatory lipids created by symbionts from dietary amino acids: Nature
Specialized transendothelial dendritic cells mediate thymic T-cell selection against blood-borne macromolecules: Nature Communications
A bacterial bile acid metabolite modulates Treg activity through the nuclear hormone receptor NR4A1: Cell Host & Microbe
Interferon-α-producing plasmacytoid dendritic cells drive the loss of adipose tissue regulatory T cells during obesity: Cell Metabolism
Not-so-opposite ends of the spectrum: CD8+ T cell dysfunction across chronic infection, cancer and autoimmunity: Nature Immunology

cIAP1/2 antagonism eliminates MHC class I-negative tumors through T cell-dependent reprogramming of mononuclear phagocytes: Sci Transl Med

Microbes in your gut may be new recruits in the fight against viruses: National Geographic
Single-cell analysis of FOXP3 deficiencies in humans and mice unmasks intrinsic and extrinsic CD4 + T cell perturbations: Nature Immunology
PPARγ marks splenic precursors of multiple nonlymphoid-tissue Treg compartments: PNAS
The CysLT2R receptor mediates leukotriene C4-driven acute and chronic itch: PNAS
Maternal immune activation in mice disrupts proteostasis in the fetal brain: Nature Neuroscience
The intestinal neuro-immune axis: Crosstalk between neurons, immune cells, and microbes: Mucosal Immunology
Facundo Batista appointed Chief Editor of The EMBO Journal: EMBO Journal
Gut CD4+ T cell phenotypes are a continuum molded by microbes, not by TH archetypes: Nature Immunology
Lymph nodes are innervated by a unique population of sensory neurons with immunomodulatory potential: Cell
Fiber Sets up the Battleground for Intestinal Prevotella: Cell Host & Microbe
Commensal Microbiota Modulation of Natural Resistance to Virus Infection: Cell
Transcriptional and proteomic insights into the host response in fatal COVID-19 cases: PNAS
Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamsters: Nature Medicine
A bilateral tumor model identifies transcriptional programs associated with patient response to immune checkpoint blockade: PNAS
XBP-1 and the unfolded protein response (UPR): Nature Immunology 
The PD-1 Pathway Regulates Development and Function of Memory CD8+T Cells following Respiratory Viral Infection: Cell Reports
Molecular Pathways of Colon Inflammation Induced by Cancer Immunotherapy: Cell
Vaccines can protect against COVID-19 in nonhuman primates, study says: Harvard Gazette
When Lab Mice Go Wild, Fungi Are in Play: Cell Host & Microbe
An immunologic mode of multigenerational transmission governs a gut Treg setpoint: Cell
The Society for Immunotherapy of Cancer Announces Three Recipients of the 2020 Richard V. Smalley, MD, Memorial Award and Lectureship: SITC
Neuro-immune Interactions in the Tissues: Immunity
Neuronal, stromal, and T-regulatory cell crosstalk in murine skeletal muscle: PNAS
Sex-specific adipose tissue imprinting of regulatory T cells: Nature
Potent Zika and dengue cross-neutralizing antibodies induced by Zika vaccination in a dengue-experienced donor: Nature Medicine
Flesh-eating bacteria is real and this is how it works: Seeker
Profile of Dennis L. Kasper: PNAS
Maternal microbiome protects newborns from deadly diarrheal infections: Genetic Engineering & Biotechnology News
Microbiota-targeted maternal antibodies protect neonates from enteric infection: Nature
Bile Acid Metabolites Keep the Gut’s T Cells in Good Humor: Genetic Engineering & Biotechnology News
Microbial bile acid metabolites modulate gut RORγ+ regulatory T cell homeostasis: Nature
Evaluation of a mosaic HIV-1 vaccine in a multicentre, randomised, double-blind, placebo-controlled, phase 1/2a clinical trial (APPROACH) and in rhesus monkeys (NHP 13-19): Lancet
T cell receptor specificity drives accumulation of a reparative population of regulatory T cells within acutely injured skeletal muscle: PNAS
Symbionts exploit complex signaling to educate the immune system: PNAS
Gut-Innervating Nociceptor Neurons Regulate Peyer’s Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense: Cell
Bile acid metabolites control TH17 and Treg cell differentiation: Nature
NMD Takes the Immune Road to NDD: Neuron
Control of Germinal Center Localization and Lineage Stability of Follicular Regulatory T Cells by the Blimp1 Transcription Factor: Cell Reports
The Immune-Mind Connection: Cell
A New Actor in Cancer Immunity: HMS News
T cell activation depends on extracellular alanine: Cell Reports
PTPN2 regulates the generation of exhausted CD8+ T cell subpopulations and restrains tumor immunity: Nature
Lack of therapeutic efficacy of an antibody to α4β7 in SIVmac251-infected rhesus macaques: Science
Programmable bacteria as cancer therapy: Nature
Transnuclear mice reveal Peyer's patch iNKT cells that regulate B-cell class switching to IgG1: EMBO Journal
Mast Cells Get on Your Nerves in Itch: Immunity
Microbiome-on-a-Chip Paves Way for Personalized Medicine: Technology Networks
The IRE1 endoplasmic reticulum stress sensor activates natural killer cell immunity in part by regulating c-Myc: Nature Immunology
Structural topology defines protective CD8+ T cell epitopes in the HIV proteome : Science
Could inflammation be the cause of myriad chronic conditions?: Harvard Magazine
Arlene Sharpe's Science Helps Cancer Patients, And 'It Doesn't Get Better Than That': WBUR
GM-CSF, IL-3, and IL-5 Family of Cytokines: Regulators of Inflammation: Immunity
Dougan Discusses Augmenting T-Cell Activity in Pancreatic Cancer: OneLive
Cracking Tumor Defiance: Harvard News & Research
Advancing Research in Neurodegenerative Diseases: Harvard News & Research
Out of One, Two. New preclinical departments emerge from MBIB: Harvard News & Research
Spurring Innovation. $14M in dean’s grants awarded to boost scientific collaborations: Harvard News & Research
Combination therapy targets latent reservoir of HIV: BIDMC News
Molecular diversification of regulatory T cells in nonlymphoid tissues: Science Immunology
Subversive Maneuvers. Study reveals how the germ behind flesh-eating disease hijacks neurons to avoid immune destruction and ensure its own survival: Harvard News & Research
Personal cancer vaccines show promise: The Harvard Gazette
4 HMS Faculty Elected to NAS: Harvard News & Research
More Options For Cancer Immunotherapy: Science Friday
Deadly Crosstalk. Nerve cells found to suppress immune response during lethal lung infections: Harvard News & Research
The SMC5/6 Complex Interacts with the Papillomavirus E2 Protein and Influences Maintenance of Viral Episomal DNA: Journal of Virology
Needle in a Haystack. Research paves way to understanding of cause and effect between gut microbes and disease: Harvard News & Research
Studies help explain link between autism, severe infection during pregnancy: MIT News

Protecting the Guardians. Gut bacteria can alter the protective effects of a gene that wards off type 1 diabetes: Harvard News & Research